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While most evidence points to an invasion from the Mediterranean at the end of the 19 th century 21 , an earlier invasion of the Pacific Islands from the Americas is plausible, given historical records of arboviral disease outbreaks in Southeast Asia 61 and early outbreaks of dengue in New Caledonia specifically 60

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3.3 TRPM The TRPM family consists of eight members (TRPM1TRPM8), expressed in cells distributed in different tissues, such as the retina, kidney, pancreas, prostate, heart, intestine, and immune system (Huang et al., 2020

At therapeutic plasma concentrations levofloxacin does not alter CYP450 enzymes activity, thereby not being relevant for drug interactions at this level (Levaquin, 2008

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