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Among many sources of 3 and 6, additives such as seeds, nuts, vegetable oils and vegetable oil-based spreads are the richest source, however, eicosapentaenoic acid (EPA) and DHA 3 can be found in seafood, particularly fatty or oily fish, and supplements like fish oils, while ARA 6 can be located in meat and eggs (Miles et al., 2021)

An anti-MITF small interfering RNA conjugated to a skin-penetrating peptide in a cream formulation was also successfully used for the treatment of patients with melasma, with an almost complete restoration of skin color on facial lesions after 12 weeks [110], but these agents need optimized topical delivery systems [111]

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They are made up of several hundred figures ranging from simple designs to complex lines