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978 An open-label randomized noninferiority study (NCT02041299) on SCD patients showed that DFP and DFO were equally effective in reducing liver iron concentrations, with acceptable efficacy and safety, consistent with results seen in transfusion-dependent thalassemia patients

Briefly, female BALB/c mice (6 weeks old) were fasted for 12 h, and a small amount of sterile medical-grade lubricant was applied to the anal region prior to rectal administration to facilitate insertion and minimize mechanical irritation

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Nilsen J, Bern M, Sand KMK, Grevys A, Dalhus B, Sandlie I, et al