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The thyroid gland is, however, largely independent from dietary selenium intake and thyroid selenoproteins are preferentially expressed

2 O 2 and other reactive oxygen species that can lead to hemolytic anemia, favism (especially in G6PD Mediterranean), chronic non-spherocytic hemolysis, spontaneous abortions, and neonatal hyperbilirubinemia resulting in neonatal kernicterus

To confirm that haem-assisted dimerization of PGRMC1 occurs in solution, we analysed the structure of apo- and haem-bound PGMRC1 by two-dimensional nuclear magnetic resonance (NMR) using heteronuclear single-quantum coherence and transverse relaxation-optimized spectroscopy (Supplementary Figs 6b and 7)