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Rosin DL, Hettinger BD, Lee A, Linden J

Glutamate serves a crucial role in the growth and development of malignant breast cancer cells, with its levels primarily regulated by amino acid transporters, notably SLC1A5 and SLC7A5 (56)

However, the U597S variant is unable to move electrons beyond the C154-C159 pair and therefore the thiolate-FAD charge transfer is sustained, confirming the proposed role of the C596-U597 disulfide