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ACKNOWLEDGEMENTS No funding was provided to contribute to the completion of this manuscript

Abstract Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or l-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver

The application of small-molecule inhibitors or siRNA-mediated knockdown of ATF4 has been shown to attenuate M-CSF secretion and limit M2 macrophage infiltration (183), which in turn impedes the progression of infantile hemangioma while simultaneously counteracts the pro-tumorigenic properties of TAMs (122)