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Sodium tanshinone IIA sulfonate is effective in treating COPD, which can alleviate inflammatory response and prevent acute exacerbation of COPD by inhibiting the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) ( Inhibiting mitochondrial fragmentation has multiple effects in COPD, which improves mitochondrial function, alleviates inflammatory response, and reduces cell apoptosis

This phenomenon does not occur with intravenous administration

** Daily values have not been determined

Statistical analysis The meta-analysis of comparable data was performed using Review Manager 5.0.2 (the Nordic Cochrane Centre, the Cochrane Collaboration, 2008)

The concept of two hormones and one receptor to explain the different actions of androgens has been generally accepted and, according to the information available from the human genome project, it is very unlikely that additional genes exist coding for a functional nuclear receptor with androgen receptor-like properties (25)