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Why does brain metabolism not favor burning of fatty acids to provide energy

11:e4257

When early tangle-bearing neurons undergo ferroptosis, the released free iron triggers neighboring microglia to initiate ferritin synthesis, aiming to lower extracellular iron concentration through intracellular sequestration (138, 139)

J.PellerinL

368,369,370 HSF2 and DLG2 can block the oligomerization of ASC by interfering with the interaction between ASC and NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the upregulation of IL-1 expression and alleviating the inflammatory response