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It differs significantly from traditional apoptosis, pyroptosis, and necrosis ( 2.2.1 Lipid peroxidation and Fenton reactions Lipid peroxidation is the core molecular event in ferroptosis ( 2.2.2 Glutathione Peroxidase 4 (GPX4) and its role in ferroptosis GPX4 is a selenoprotein that plays a central role in suppressing ferroptosis by catalyzing the reduction of membrane-bound phospholipid hydroperoxides (PL-OOH) into their corresponding non-toxic alcohols (PL-OH), thereby preserving lipid bilayer integrity under oxidative stress ( Beyond its classical enzymatic role, GPX4 is subject to multifaceted regulation

In addition, some bioengineered skin substitutes such as Dermagraft and Apligraf have been developed to accelerate the healing of venous ulcers (Nicholas 2016

After undergoing the specified treatments, osteocytes were thoroughly rinsed with HBSS solution and subsequently exposed to 1 M FerroOrange probes (DOJINDO, Japan) for a duration of 30 min

Dolovich, M