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Clinically, congestion was reduced by perivascular and perialveolar inflammatory cell infiltrate and fluid extravasation that destroys alveolar walls (Fig

PDRN is too large to passively cross intact stratum corneum, which is why it benefits significantly from microinfusion delivery

By 8 weeks p.i., a more pronounced difference was observed, with approximately an 8.9-fold reduction in the bacterial burden in the lungs of metZ- infected animals compared to those infected with the Rv-WT strain

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