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Interestingly, products of lipid peroxidation may further increase overall cellular oxidative stress by facilitating the generation of free radicals through the formation of adducts with proteins, which increases direct free radical-induced protein oxidation (67)

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For example, the apoptosis of HepG2 cells can be significantly inhibited by specific cathepsin B inhibitors 95,101

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10.1016/S1474-4422(18)30461-7 99 LeveyA

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Cancer Cell (2018) 34(5):724740.e4

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Prednisone is the most common corticosteroid

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