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9 Factors such as fish species, diet, environmental conditions, and dosage affect the efficacy of probiotics, prebiotics, and synbiotics The efficacy of probiotics, prebiotics, and synbiotics in aquaculture is influenced by a variety of factors, including fish species, diet, environmental conditions, and dosage (Cerezuela et al., 2013

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IGFALS knockout mice showed 60% reduction in serum IGF-1, and also 90% reduction in IGFBP-3 [100]

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