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Every vial is labelled and supplied for in-vitro research use only

The best way to treat melasma depends upon the individual, but all treatment needs to include both active treatments to remove the pigment in the skin AND a proactive skincare and medication routine to prevent new pigment from developing

This parameter, along with its size as molar volume (V m in cm 3 /mol) and its topological polar surface area (TPSA in 2 ), determines niclosamides propensity to partition into lipid bilayer membranes, actually as the parameter, LogB (LogBilayer)

Data Availability All data generated or analysed during this study are included in this published article (and its Supplementary Information file)

The binding pose of the naphthylsulfonic acid core of the analogues was constrained to the leucine pocket, imitating the binding mode of 32 , whilst the substituted benzyl group was left unconstrained in the phenylalanine pocket