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Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase

Moreover, NAC inhibits mitochondrial ETC complex I, reduce the oxidative stress (159, 160), diminish serum anti-dsDNA antibodies and improves lupus nephritis as well as prevent disease flares in lupus mice (161)

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Bound proteins were eluted with His elution buffer (50 mM Tris-HCl pH 7.5, 50 mM NaCl, 250 mM imidazole, 2.5 mM ME)

Further investigation is warranted to determine whether targeting local iron export mechanisms could alleviate ferroptosis-related cartilage degeneration