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Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells

Sensing systems fluorescence was restored by addition of GSH because GSH degraded and reduced MnO 2 into Mn 2+ ions, which caused MnO 2 nanosheets to release carbon dots subsequently

A subsequent larger RCT (n=72) confirmed these findings, showing improvements in gait speed, grip strength, exercise capacity, waist circumference, and systolic blood pressure (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]

We identify STING, NEMO, OPTN and ANKIB1 itself as substrates of ANKIB1 and show, by using ANKIB1-RING1 mut cells, that the catalytic activity of ANKIB1 enables OPTN and TBK1 recruitment, contributing substantially to IRF3 activation and type-I and type-III IFN production