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The last thing we want to hit on is that any supplement containing sugarnatural or artificial (pre-workouts included)should be avoided during a fast, as it will trigger insulin release

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doi: 10.3390/jcm12041452

Hence, medication repurposing, such as metformin for asthma, represents a near-term opportunity for clinical trials, especially in patients with metabolic comorbidities, providing a useful test of the concept that modulation of these intracellular pathways may result in therapeutic benefit