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Mushrooms, in this case, white-rot fungi such as Ganoderma, Pleurotus , and Trametes , play an integral role in the conversion of biofuels by releasing ligninolytic enzymes (e.g., laccase, lignin peroxidase, and manganese peroxidase) which efficiently depolymerize recalcitrant plant polymers to fermentable sugars (El-Ramady et al., 2022)

An encouraging strategy involves the development of small molecule inhibitors or alternative therapeutic agents that directly target FSP1, consequently augmenting the susceptibility of tumor cells to GPX4 inhibitors [252]