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In a randomized, placebo-controlled phase-1 window trial, a curcumin-containing botanical (APG-157) achieved measurable systemic absorption and reduced salivary pro-inflammatory cytokines (IL-1, IL-6, IL-8) and tumor-associated microbes in OSCC patients (PDQ Integrative et al., 2024)

This finding suggests a potential role for valeric acid in modulating tumor progression and immune responses (Figure 1A)

Follow-up health assessments guide future infusion choices

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Additionally, the ELISA results demonstrated that both Fer-1 and QCT significantly alleviated the inflammatory and angiogenic imbalance