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In 2016, researchers first designed phosphate and pyrophosphate-containing linkers coupled with the well-established, cathepsin B sensitive, Val-Cit-PABA moiety aiming to deliver glucocorticoids

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NRF2 is a pivotal transcription factor of PHGDH, and its SUMOylation promotes SSP by transcriptionally upregulating PHGDH, maintaining HCC tumorigenesis in response to metabolic stress [117]

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