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& Bouma, H

Med 330 , 962968 (1994)

Collectively, these findings indicate that the disulfide bond in MB-NO can be selectively cleaved by the elevated concentration of reducing agents present in the TME

Study: Phase 3 REGENCY trial (NCT04221477) with 271 patients Primary Endpoint: Complete Renal Response (CRR) at Week 76 Results: Significantly higher CRR rates with Obinutuzumab + standard therapy Clinically meaningful improvements in steroid tapering and renal outcomes If approved, Obinutuzumab could offer a new biologic option for patients with severe lupus nephritis

bFGF contributes to tendon healing by enhancing neovascularization, cell proliferation and collagen synthesis, and it also regulates the growth of fibroblasts