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It differs from the processes of apoptosis and autophagy in its particular mechanism of action and physiological significance [61]

Pharmacol Ther 73(3):265280 Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT (1992) Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62

Apoptosis, primarily driven by caspase family activation, is the dominant leukocyte death program associated with late-phase immune depletion and immunosuppression in sepsis

It is soluble in water and can be found in both oxidized and reduced forms