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The accumulation of LCACs during mitochondrial FAO disorders can inhibit the activity of PPAR/PGC1, destroy the regeneration of peroxisomes, lead to increases in BCAA and ROS levels, and activate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway

Amino Acids 45(3):413418 Bchold C, Hils M, Gerlach U, Weber J, Pelzer C, Heil A, Aeschlimann D, Pasternack R (2022) Features of zed1227: the first-in-class tissue transglutaminase inhibitor undergoing clinical evaluation for the treatment of Celiac disease

Reference Edwards, Buono, Fordham, Skipsey, Brazier, Dixon and Cummins2005

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Gen-gen ini terlibat dalam memproduksi enzim yang memungkinkan tubuh untuk menciptakan dan mendaur ulang Glutathione (GSH) di dalam tubuh