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Further studies suggested that the mechanism might involve the suppression of the TLR4/MyD88/NF-B signaling pathway by AS-IV, which downregulates the expression of downstream inflammatory cytokines such as TNF-, IL-6, and IL-8, thereby alleviating the inflammatory response induced by liver steatosis (Liu et al., 2020)

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Probio-M8 improved microbial interactions (e.g., among Bifidobacterium , Eubacterium , Cyanobacterium , and Ruminococcus ) within the GM of PMOP, specifically enhancing butyrate synthesis while diminishing the prevalence of Ruminococcus , which has been inversely connected with OP (112) found that altitude was negatively correlated with BMD