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Like other proteins, the digestive system breaks glutathione into its basic componentsglycine, cysteine, and glutamate

Biosci Biotechnol Biochem 61(12):19771980 Van Der Werf P, Orlowski M, Meister A (1971) Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle

Additionally, the pathophysiological mechanisms contributing to HF may be complex, not solely attributed to left ventricular systolic dysfunction and volume overload but also potentially linked to right ventricular impairment or HF with preserved ejection fraction (HFpEF) (Ngele and Flammer, 2022)

Saline (0.9% NaCl) can be used but may affect solubility of some peptides

A mild acidic NaCl aqueous solution (0.1 M, pH = 6.6) as the supporting electrolyte solution was added with MnCl 2 (1 mM) or MnTCPP + monochloride ([Mn] = 1 mM) or ZMTP nanosheets ([Mn] = 1 mM) and purged with nitrogen for 10 min before CV measurements