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Extensive oxidation of PUFA-containing phospholipids alters the membranes phase structure and permeability, resulting in plasma membrane rupture in response to lipid-ROS accumulation, such as lipid hydroperoxides [45]

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A glutathione deficiency can have several negative consequences for the body's health and well-being, because it impairs immune system function, increases oxidative stress, causes liver damage, reduces the capacity to repair DNA and increases sensitivity to drugs and toxic substances