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Description

Gut microbiota-dependent trimethylamine n-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

Clin Rheumatol (2018) 37:203542

TMAO reduces synaptic plasticity and induces cognitive dysfunction by promoting endoplasmic reticulum stress and directly binding to activate PERK, which damages synaptic plasticity (Zhang et al., 2007