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Deciphering flux adjustments of engineered E

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Arginase is an enzyme that metabolizes L-arginine into L-ornithine and urea, and is associated with endothelial dysfunction and aging, which have two isoforms, namely arginase 1 (Arg1) and arginase 2 (Arg2), with Arg2 being the predominant isoform induced in human ECs mitochondria (Yang and Ming, 2013

Secondly, as a retrospective analysis based on public datasets, this study is characterized by a relatively homogeneous study cohort