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doi: 10.1002/adhm.202100985

Kenneth Koncilja, a Geriatrician at Cleveland Clinic, sums it up well: "Your liver just isn't as resilient as you get older

SUMOylation regulates the transcriptional activity of NRF2, affects its interaction with other proteins and intracellular localization, and protects NRF2 from ubiquitination-mediated degradation [129]