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whereas stiffer substrates promote osteogenic differentiation (Navaro et al., 2015

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A number of surgical strategies have been described, but there is insufficient evidence to advocate one repair technique over another

Standard Dosing Range: Low dose: 200 to 250 mcg once daily Moderate dose: 250 to 500 mcg once or twice daily Higher dose: 500 to 800 mcg once or twice daily Weight-Based Dosing: Based on animal study extrapolations, an estimated human equivalent dose is approximately 1.6 mcg/kg body weight, translating to roughly 110 mcg for a 150-pound person and 145 mcg for a 200-pound person when using oral administration

Furthermore, supplementation with 1 g/kg GO led to a significant upregulation in the mRNA levels of the tight junction proteins zo-1 and Claudin-1 (Fig