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Although the ferroptosis axis targeting macrophages shows therapeutic potential, key issues still need to be addressed: developing nanoscale vectors with spatiotemporally specific regulation (such as pH or ROS-responsive), precisely regulating iron release and macrophage polarization

Oral and topical glutathione are usually well tolerated

"Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study." Lancet 361 (2003): 14961501