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The chronic inflammation caused by visceral fat activates the immune system, diverting energy from the brain

During prolonged periods of starvation or illness, subcutaneous fat is broken down into fatty acids (FAs) and glycerol to provide the body with essential nutrients (10)

Under oxidative stress, the p53 protein forms a complex with cyclophilin D (CypD) in the mitochondrial matrix, opening the mitochondrial permeability transition pore and leading to the release of mitochondrial contents, which induces cell necrosis (Wu et al., 2020

6 (2020): 155473.e12

Neuronal cell cultures are essential for understanding the basic mechanisms underlying the neuroprotective effects of resveratrol