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Due to the important role of glutamine in hepatic metabolism, many studies have investigated this amino acid in liver injury situations [4446]

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Whereas wild-type proinsulin efficiently folds to form a single dominant product (in accordance with classical studies), the clinical variants exhibited marked impairment, especially at neutral pH

Ethics statement The animal studies were conducted in accordance with the recommendations of the European Community (Directive 2010/63/EU, 1 January 2013)

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