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In the FSL rats, a combined treatment with sodium salicylate, which is a non-selective inhibitor of NF-B, counteracted the antidepressant effect of LAC on the expression of mGlu2 receptors, supporting the link between LAC-mediated mGlu2 induction and p65/NF-B [30]

The last stage, dispersion, is a regulated process by which biofilm bacteria escape the sessile mode of growth as a means of self-preservation, and transition to the planktonic, free-living mode of growth 14,17

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Table 1 The negative effects of TMAO on atherosclerosis demonstrated via clinical and non-clinical experiments