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In contrast, at high concentrations, the cytotoxic effects of vitamin C outweigh its protective properties

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Patients on lower doses (200 to 300 mcg) may tolerate longer continuous periods before receptor sensitivity concerns arise, while patients on higher doses (400 to 500 mcg) may benefit from more frequent cycling

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Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation