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Vill K, Muller-Felber W, Landfarth T, Koppl C, Herzig N, Knerr C, Holla H, Steidle G, Harms E, Hohenfellner K, Interdisciplinary Cystinosis Group (2022) Neuromuscular conditions and the impact of cystine-depleting therapy in infantile nephropathic cystinosis: a cross-sectional analysis of 55 patients

PnAc enabled the demonstration of an exacerbated lipid peroxidation in the mitochondrial membranes of CFBE41o-cells compared to 16HBE14o-cells, thereby adding to the cumulative evidence of increased oxidative damage at the mitochondrial level in CF (Atlante et al., 2016)

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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models