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Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

10.1016/j.devcel.2014.11.012 Dev

It also has a relatively short lifespan (~3 weeks compared to ~3 months for flies or ~3 years for mice), a fully-sequenced genome, and contains numerous conserved cysteines in the proteome

Cationic lipid, DSPC, cholesterol and PEG-lipid were solubilised in ethanol at a molar ratio of 40/10/40/10, respectively

The subcellular distribution of the S114A mutant favored a more pronounced nuclear localization with significantly less fluorescence in the cytosol compared to the full-length transgene (Fig