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Stefanatos and Sanz, 2018)

10.3389/fpls.2022.1064412 147 JaremekA.JeyarajahM

IGF binds to its cell surface receptors such as type I insulin-like growth factor receptor (IGF-IR) and then initiates multiple signaling pathways including PI3K/Akt, MAPK, JAK/STAT, Src, and focal adhesion kinase (FAK), which act in concert to stimulate cancer cell proliferation, survival and migration