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Moreover, perturbation of the TCA cycle can disrupt bacterial energy homeostasis, leading to alterations in antibiotic targets or enhanced utilization of alternative metabolic pathways that significantly bolster bacterial viability (Yao et al., 2024)

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Furthermore, it highlights the role of NAD + in mitochondrial homeostasis in aging and disease conditions, the latest results of NAD + -boosting therapeutics in clinical trials, and areas of further translational development