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When the serum transferrin saturation is about 60%-70%, exceeding the transferrin binding capacity, it forms the NTBI, also known as the unstable iron pool

Talukdar and Talukdar, 2014) and Pro (Omidi, via decreasing H 2 O 2 level and maintaining an increased level of reduced GSH and GSSG/GSH ratio

Clozapine and olanzapine also have the greatest potential clinical metabolic liability in that they potently induce weight gain/obesity and increased incidence of type 2 diabetes across the lifespan when compared to other antipsychotic medications (Holt, 2019)

10.1016/0753-3322(96)82645-X

These findings suggested that metabolomic changes in depression models are characterized by decreased neurotransmitter and increased kynurenine metabolite levels in the brain, decreased amino acid and increased corticosterone levels in blood, and imbalanced energy metabolism and microbial metabolites in urine