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Referring to the tissue distribution of silymarin it can be concluded from different studies in patients with colorectal carcinoma and studies in mice [34] that the highest tissue [35] concentration was found in the colon [36] whereas the lowest concentration was detected in the brain and the prostate [35, 37]

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10.1371/journal.pone.0219531 127 NewtonJ

Stacking MOTS-C: Complementary Protocols and Synergistic Combinations MOTS-c does not operate in isolation in a sophisticated longevity protocol, and understanding which combinations are mechanistically justified versus speculative is important for responsible prescribing