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56 The expression of selected genes was quantified by real-time PCR using Step One (TM) sequence detection system (Applied Biosystems Inc, Milan, Italy)

doi: 10.1371/journal.pone.0259565 4

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

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Suppression of GSTP at the transcript level induced oxidative stress based on mechanisms that intervened in mitochondrial homeostasis, which might be more rapidly and strongly than suppressing the expressed GSTP protein