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In the recently completed parallel-group phase 1 clinical trial, the AFF008 study series assessed the tolerability and safety of repeated subcutaneous administration of a synthetic -syn mimicking epitope called AFFITOPE PD01A in a group of 24 patients randomized to receive either AFFITOPE PD01A low dose or high dose (NCT01568099)

83 TRAF members trigger the disassembly of the receptor-ligand complexes and further trigger the activation of NIK

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Morgan ET, Koop DR, Coon MJ: Comparison of six rabbit liver cytochrome P450 isozymes in formation of a reactive metabolite of acetaminophen

Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography