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In this aspect, astrocytic terminal processes, known as endfeet, contact the brain vasculature and enwrap the neuronal synapses, enabling the modulation of both neuronal activity and cerebral blood flow, following an elevation in intracellular Ca 2+ levels in the endfeets [24,29]

However, when the concentration of CORT exceeds 300 ng/ml, the protein expression level of NLRP3 gradually decreases, reaching its lowest level at 700 ng/ml, along with a decrease in activated caspase-1 expression

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These in-organ changes in energy metabolism are also reflected in the plasma metabolome after ischemic AKI, which is characterized by the depletion of numerous amino acids and energy substrates 6

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