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Optimal timing of assessment Given the insidious and progressive nature of neurodegenerative diseases, the utility of a single biomarker measurement is questionable

Many studies have indicated that tumor tissue is a constantly evolving ecosystem contained a wide variety of cells with different phenotypes and mutations, such as cancer cells, tumor-associated fibroblasts, immune cells, cells related to blood vessels and so on, the gene mutations and epigenetic regulation of which caused by WM treatment could synergistically promote drug resistance and immune escape of cancer cells by rebuilding tumor microenvironment (TME)

Young S, McDonald K, Newberry R, Clarke L (2021) Evaluating the role of goblet cell associated antigen passages (gaps) in the development of mucosal immune tolerance in the cftr ko intestine

Primary outcome was the incidence of HCC with a median follow-up period of 6.2 years

Cancer metabolism: looking forward