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Many people choose B12 injections for general wellbeing and energy support even without a clinical deficiency

The value of another blood test, holotranscobalamin (HoloTC), decreases with vitamin B12 deficiency

Nicotinamide N-methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine (SAH)

[29] It has also been linked to optic nerve atrophy and neuritis

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