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doi: 10.3390/ani13010097 29

In 2017, the first CD38-targeting sdAbs were developed by the group of Koch-Nolte, who identified 22 different CD38-specific sdAb families capable of recognizing the three different epitopes (E1, E2, E3) of CD38

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IL-1 ubiquitylation on lysine K133 promotes IL-1 turnover, and loss of IL-1 K133 ubiquitylation via the generation of Il1b K133R/K133R mice enhances i) pro-IL-1 protein levels, ii) the capacity of IL-1 to be activated following NLRP3 triggering, and iii) increases levels of precursor and activated IL-1 following LPS injection