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UPLC-HRMS analysis UPLC-HRMS analyses were performed using a Waters ACQUITY UPLC I Class system fitted with a Waters ACQUITY UPLC BEH C 18 column (2.1 100 mm, 1.7 m particle size, Waters Corporation, Milford, MA, USA, catalogue #186002352), and coupled to a Xevo G2S QTOF mass spectrometer (Waters Corporation, Manchester, UK, SN: YDA 375) with an electrospray ionization (ESI) source operated in ESI positive ionization mode

However, in vivo macrophages are highly specialized, transcriptomically dynamic and extremely heterogeneous with regard to their phenotypes and functions, which are continuously shaped by their tissue microenvironment

In one study in primary human umbilical vein endothelial cells, an increase in the pro-inflammatory cytokine interleukin-6 (IL-6) was observed

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