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Left ventricular hypertrophy is a hallmark of CKD and the main factors underlying its development include insulin resistance, accumulation of endogenous cardiotonic steroids and uraemic toxins, vitamin D deficiency, hyperphosphataemia and haemodynamic overload, which induces mechanical stress

Single-cell RNA sequencing and spatial transcriptomics are novel approaches that provide deeper insights into the cellular heterogeneity in DPN pathogenesis

Compared with the parent natural medicines, their derivatives have attracted much attention due to their stronger pharmacological effects

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Dosage And Administration Give by subcutaneous, intramuscular or intravenous injection according to the following table: HUMAN WARNINGS: For animal use only