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When the body lacks this vital vitamin, several symptoms can occur: Common Symptoms: Fatigue and weakness Tingling or numbness in hands and feet Memory issues Mood swings or depression Loss of appetite Common Causes: Vegetarian or vegan diet (B12 is mostly found in animal-based foods) Poor gut absorption Long-term use of certain medications (e.g., metformin, antacids) Aging What Happens If Left Untreated

Liver iron overload is a common and severe pathological feature of HS, a consequence of chronic hemolysis and inappropriate hepcidin downregulation (41, 44, 45)

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It plays a significant role in cellular processes such as metabolism, DNA repair, and chromatin remodeling, which are vital for maintaining tissue and metabolic homeostasis