glutathione concentration in brain Frontiers Neuronal glutathione loss leads to

J Proteome Res 15:11161125 Letourneau JM, Ebbel EE, Katz PP, Oktay KH, McCulloch CE, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP (2012a) Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer

It also minimizes the activity of free radicals in the body, preventing the activation of melanin-producing enzymes

Funding: Swiss National Science Foundation and PT national funds (FCT/MCTES, Fundao para a Cincia e Tecnologia and Ministrio da Cincia, Tecnologia e Ensino Superior) through grant UIDB/QUI/50006/2020 and UIDP/50006/2020

Impaired clearance of oxidatively modified proteins can cause their aggregation and directly promote the progression of the neurodegenerative process (Grune et al., 2004)

To safely use it in a clinical setting, it needs to be started slowly, with personalized patient education, and metabolic indicators like HbA1c, fasting glucose, and lipid panels need to be closely watched to weigh the benefits against the risks